[https://apple.news/As_R3DBUiRGmq87Yw_WDpUw](https://apple.news/As_R3DBUiRGmq87Yw_WDpUw) >"Taking tiny doses of drugs like psilocybin, LSD, and ayahuasca is gaining popularity. But the benefits are still being investigated." “But many who are intrigued by the promise of psychedelics—a category that includes psilocybin, lysergic acid diethylamide (LSD), ayahuasca, mescaline, and other substances that alter consciousness—are eager to reap the benefits without having to take a dose strong enough to provoke an hours-long journey down the rabbit hole. A growing number are turning to microdosing, regularly ingesting five to 10 percent of the mind-bending amount in a quest to enhance well-being, improve work, or diminish depression and other psychological demons without triggering the drug’s full effects. But experts say there is little scientific evidence so far to support this approach. Experts also worry that microdosing on a regular basis for a long period of time could theoretically weaken heart valves, like the damage caused by the diet drugs phentermine and fenfluramine (Phen/Fen) in the 1990s. Both Phen/Fen and psychedelics act on one of the body’s serotonin receptors, known as 5-HT2B, Johns Hopkins’ Garcia-Romeu says.”